Research abstract

Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with ADHD/HKD

The aim of this study at the Medical University, Bialystok, Podlaskie (Poland) was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder.

Abstract
The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder.
The study group comprised 37 Caucasian boys aged 7-12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (? = 0.33; p = 0.043) and HKD (? = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (? = 0.38; p = 0.019).

Medical University, Bialystok, Podlaskie, Poland. Research team: Halina Kadziela-Olech, Piotr Cichocki, Justyna Chwiesko, Jerzy Konstantynowicz, Jan Józef Braszko.
Published before in the ECAP Journal, 17 March 2014, open access, online.

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