“Considerable overlap.” Herman van Engeland
ESCAP 2009 Congress in Budapest, Hungary: original abstract by professor Herman van Engeland (Netherlands) – “Autism and Schizophrenia: a Reappraisal.” Plenary Session V., 24 August 2009, 09:00, Chaired by H. Remschmidt (Germany).
1. Parents with schizophrenia have an increased risk of offspring with autism. Youngsters with early onset schizophrenia often have a prior diagnosis in the autism spectrum.
2. Children with atypical autism have a greatly increased risk of schizophrenia.
3. In some genetic syndromes, such as Klinefelters syndrome and the 22q11.2 deletion syndrome, autism and schizophrenia do co- occur in the same child.
An increased number of Minor Physical Anomalies and Copy Number Variations were found in both disorders. There is a considerable overlap in candidate genes for autism and schizophrenia. The question is raised whether psychiatric disorders can be unambiguously demarcated. Are there only smooth transitions in our biological reality „And”. What does that mean for our current classification systems? Should we dimensionalise instead of categorise „And” if we chose to dimensionalise, on what should we base our dimension? On symptoms or on endophenotypes?